Fortschritte in der Pharmakoepidemiologie und Arzneimittelsicherheit

Abstrakt

Inhibition of Interaction between CagA and Shp-2 Domain by Using Medicinal Plant Products

Zoltan Szomor

Aim: Inhibition of CagA tyrosine phosphorylation or disruption of the CagA–SHP-2 complex, to prevent the bacteria function which may leads to the peptic ulcers and gastric Adeno carcinoma, by using medicinal plants. The CagA–SHP-2 interaction is dependent on CagA tyrosine phosphorylation and, through the complex formation. SHP2 plays a pivotal role in growth factor and cytokine signaling. By inhibiting this CagA-SHP-2 domain complex, we can prevent the survival of the bacteria in the host. This inhibition of CagA-SHP-2 complex can be done by using various chemical compounds like NSC87877, Salicylic acid etc. These compounds have the ability to inhibit the CagA-SHP-2 domain. The functional compounds of these compounds can inhibit the CagA-SHP-2. In our study here we targeting the CagA-SHP2 complex inhibition by using some medicinal plants like quinoline compounds, black tea, turmeric, nutmeg, ginger [1]. Previous studies proven that, these medicinal plants products have the bactericidal effect on H. pylori culture, that these plants have nearly 95-100% of H. Pylori growth inhibition, it predict that these plant products can be inhibit the growth the H. Pylori culture, so here we focusing on that these plants can able to inhibit the CagA-SHP-2 domain complex.