Einzelzellbiologie

Abstrakt

Toll-Like Receptor 11: Role in Kidney Infections After Transplantation

Indra Mani and Kavita Vasdev

Uropathogenic microorganisms interact with the mucosa of the intestinal tract, which activates immune cell responses via the Toll-like receptors (TLRs). TLRs are single, membrane-spanning, non-catalytic proteins and play an important role in the innate immune system. Recent studies have shown that TLRs are expressed in sentinel cells such as dendritic cells and macrophages, which recognize structurally conserved molecules derived from microorganisms. Interestingly, massive renal infection was observed in the TLR11 knockout mice, supporting the hypothesis that TLR11 represents a barrier that prevents uropathogenic bacteria from specifically infecting the kidneys after transplantation.