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Abstrakt
Synthesis, Pharmacological Evaluation and Molecular Docking of Some Pyrimidinyl Hydrazones
Indu Ravish and Neera Raghav
The diagnostic enzymes, acid and alkaline phosphatases are used as investigative tool for the identification of various diseased conditions. It has been reported that elevated levels of acid phosphatase and alkaline phosphatase are present in different cancerous conditions. In-vitro enzyme related studies emphasize the potential of remedial uses of various compounds. In the present work we report the effect of hydrazones on the activities of these two clinically significant enzymes. The data revealed that most of the compounds inhibited enzymes. 2-(4,6-Dimethylpyrimidin-2-yl)-1- [1-(6-nitrobenzaldehyde)ethylidene]hydrazine has been evaluated as the most effective inhibitor of these phosphatases. Enzyme kinetic studies were conducted in order to establish the type of inhibition and Ki values. The observed data is explained on the basis of molecular modelling and in-silico studies.