Indiziert in
- Datenbank für wissenschaftliche Zeitschriften
- Öffnen Sie das J-Tor
- Genamics JournalSeek
- Akademische Schlüssel
- JournalTOCs
- Nationale Wissensinfrastruktur Chinas (CNKI)
- CiteFactor
- Scimago
- Ulrichs Zeitschriftenverzeichnis
- Elektronische Zeitschriftenbibliothek
- RefSeek
- Hamdard-Universität
- EBSCO AZ
- OCLC – WorldCat
- SWB Online-Katalog
- Virtuelle Bibliothek für Biologie (vifabio)
- Publons
- MIAR
- Kommission für Universitätsstipendien
- Genfer Stiftung für medizinische Ausbildung und Forschung
- Euro-Pub
- Google Scholar
Nützliche Links
Teile diese Seite
Zeitschriftenflyer
Open-Access-Zeitschriften
- Allgemeine Wissenschaft
- Biochemie
- Bioinformatik und Systembiologie
- Chemie
- Genetik und Molekularbiologie
- Immunologie und Mikrobiologie
- Klinische Wissenschaften
- Krankenpflege und Gesundheitsfürsorge
- Landwirtschaft und Aquakultur
- Lebensmittel & Ernährung
- Maschinenbau
- Materialwissenschaften
- Medizinische Wissenschaften
- Neurowissenschaften und Psychologie
- Pharmazeutische Wissenschaften
- Umweltwissenschaften
- Veterinärwissenschaften
- Wirtschaft & Management
Abstrakt
Study to Determine Bioequivalence of Three Ceftiofur Crystalline Free Acid in Pigs
Luis Ocampo-Camberos, Minerva Monroy-Barreto, Agustín Nieto-Carmona, Juan Angel Jaime, Lilia Gutierrez
Background: Antimicrobial resistance has the potential to affect sustainable development goals in food-producing livestock. Poor quality antibacterial pharmaceutical preparations significantly contribute to heighten this problem. Bioequivalence (BE) studies are very important for the development of dependable pharmaceutical preparations.
Methods: In this trial 3 Ceftiofur Crystalline Free Acid (CCFA) pharmaceutical preparations (1 reference and 2 experimental), intended for swine medicine and freely sold in Mexico, were tested to assess as to whether or not they can be regarded as generic ones.
Results: Three commercially available products of CCFA containing 200 mg of ceftiofur crystalline free acid were compared taking Excede® brand as reference preparation and preparations A and B as experimental ones. Thirty-six Landrace/Duroc pigs randomly divided into three groups received a single injection in phase 1 and after a washout period the same procedure was repeated in a crossover phase. Based on PK data obtained through HPLC analytical recollection of serum concentrations of ceftiofur, it is possible to conclude that preparations A and B cannot be regarded as bioequivalent to Excede® in pigs given that AUC0-168, MRT and K½el values obtained from preparations A and B are statistically different beyond a 20% limit from the corresponding ones obtained for the reference preparation, with confidence intervals >0.05.
Conclusion: Based on the area under the concentration vs time curve from zero to 168 h, mean residence time, and elimination constant values obtained from preparations A and B it is possible to conclude that they cannot be regarded as bioequivalent to Excede® in pigs (CI>0.05).