Zeitschrift für Neonatalbiologie

Abstrakt

Spontaneous remission in congenital leukemia AML-M1 with pericardial effusion

Ali Bülbül, Mesut Dursun, Yıldız Yıldırmak, Bedir Akyol, Umut ZübarioÄŸlu, Ebru TürkoÄŸlu Ünal, Lida Bülbül, Selcen YaroÄŸlu Kazancı and Sinan Uslu

Congenital leukemia is a very rare childhood malignancy with a poor prognosis. The incidence is approximately 1 in 5 million live births. The majority of cases are acute myeloblastic leukemia with trisomy. Clinical manifestations are usually leukocytosis, petechiae, ecchymosis, skin nodules, hepatosplenomegaly, and central nervous system symptoms. A 23-day-old girl presented with complaints of maculopapular dermatitis and hepatosplenomegaly, which was diagnosed as AML M1. During follow-up, a massive pericardial effusion was noted. This case is presented to highlight the rare association between pericardial effusion and congenital leukemia without trisomy and spontaneous remission of the leukemia, which is occasionally reported in the literature.