Yang Wang, Bingqiang Zhang and Wei Zou
The WNT family of secreted proteins plays an important role in various biological processes, including development, proliferation and differentiation, and regulates various diseases such as prostate cancer, breast cancer, glioblastoma, type II diabetes and others. The WNT ligands could activate two important intracellular signaling pathways: the so-called canonical signaling pathway, which is β-catenin-dependent, and the non-canonical signaling pathway, which is β-catenin-independent.