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Abstrakt
ROLE OF VITAMIN E ON ANTIFOLLICULOGENESIS EFFECTS OF LEAD ACETATE ON DIAMETER OF FOLLICLES CONTAINING OVARIAN TISSUE OF SWISS ALBINO MICE
Durgesh Nandini, Lata Bhattacharya
Lead is one of the oldest known and most widely studied occupational and environmental toxicant. Lead compounds are known to adversely affect the gonadal structure and functions, can cause alterations in fertility and impaired gamete function. The toxic effects of lead on adult female reproduction are decreased fertility, the inability to sustain pregnancy and reduced pregnancy outcomes. The objective of the present study was to examine the effect of oral administration of lead acetate (1.25 mg/kg) daily for 30 days on the folliculogenesis process in the mice ovary and the protective role of antioxidant vitamin E against the induced damage. Histomorphological studies of ovary exhibited remarkable damage in follicle development and reduction in follicle size.. The weight of ovary, uterus and fallopian tubules were significantly reduced in lead treated group. These changes were ameliorated with the administration of vitamin E.. The results of this study suggested that cotreatment with vitamin E has a protective role against lead induced ovarian damage in mice.