Indiziert in
- Datenbank für wissenschaftliche Zeitschriften
- Öffnen Sie das J-Tor
- Genamics JournalSeek
- Akademische Schlüssel
- JournalTOCs
- Nationale Wissensinfrastruktur Chinas (CNKI)
- CiteFactor
- Scimago
- Ulrichs Zeitschriftenverzeichnis
- Elektronische Zeitschriftenbibliothek
- RefSeek
- Hamdard-Universität
- EBSCO AZ
- OCLC – WorldCat
- SWB Online-Katalog
- Virtuelle Bibliothek für Biologie (vifabio)
- Publons
- MIAR
- Kommission für Universitätsstipendien
- Genfer Stiftung für medizinische Ausbildung und Forschung
- Euro-Pub
- Google Scholar
Nützliche Links
Teile diese Seite
Zeitschriftenflyer
Open-Access-Zeitschriften
- Allgemeine Wissenschaft
- Biochemie
- Bioinformatik und Systembiologie
- Chemie
- Genetik und Molekularbiologie
- Immunologie und Mikrobiologie
- Klinische Wissenschaften
- Krankenpflege und Gesundheitsfürsorge
- Landwirtschaft und Aquakultur
- Lebensmittel & Ernährung
- Maschinenbau
- Materialwissenschaften
- Medizinische Wissenschaften
- Neurowissenschaften und Psychologie
- Pharmazeutische Wissenschaften
- Umweltwissenschaften
- Veterinärwissenschaften
- Wirtschaft & Management
Abstrakt
Preparation and Optimization of PEG-PLGA Loaded with Vincristine Sulfate and its In vitro Release
WEN Jia-Gen, GUO Tingting, ZHU Hong-Yuan, XIAO Yi-Yun, ZHANG Xiu-Zhen, CHEN Guo and CHEN Yuxiang
The aim of this study was to prepare the PEG-PLGA loaded with vincristine sulfate nanoparticles (VCR-loaded PEG-PLGA-NPs) and investigate its in vitro release properties. VCR-loaded PEG-PLGA-NPs were prepared by the modified double emulsion (W1/O/W2) method, and the main experimental factors influencing the characteristics of the nanoparticles were investigated and the preparation was optimized. The results showed that the physicochemical characteristics of VCR-loaded PEG-PLGA-NPs were affected by the polymer concentration, the ratio of internal water phase to oil phase, external water phase to oil phase and ultrasound time for the second time. VCR-loaded PEG-PLGA-NPs, with average particle size of 135.9nm, zeta potential of -12.83mV, encapsulation efficiency of 68.2% and drug loading of 8.34%, were prepared under optimal conditions. The release experiments in vitro showed the VCR release from PEG-PLGA-NPs exhibited consequently sustained release for more than 13d, which was in accordance with Higuchi equation.