Abstrakt

Lactate dehydrogenase in the umbilical cord blood of healthy infants after different types of delivery

Eva Wiberg-Itzel, Hampus Josephson, Nana Wiberg, Linus Olson, Birger Winbladh and Mathias Karlsson

Background: LDH can be a valuable marker for some of the most important diseases in newborns, and cord blood is a non-invasive and easy way to obtain blood for analysis. The aim of this study was to determine the interval for LDH in arterial and venous cord blood at birth in truly healthy newborns.
Methods: A prospective observational study was conducted at Söder Hospital in Stockholm, Sweden, in 2011-2012. Cord blood was collected at birth and LDH was analyzed in 549 healthy infants aged > 37 weeks of gestation born to healthy mothers after an uncomplicated pregnancy.
Results: The 2.5th and 97.5th percentiles for arterial LDH were 162–612 U/L and for venous LDH 252–636 U/L. Intervals were significantly higher for instrumental delivery and acute cesarean section and significantly lower for planned cesarean section than for vaginal delivery. Hemolysis (>0.3 g/L) led to disqualification in 13-41% of samples. Conclusion: The reported LDH values ​​are consistent with previous studies and appear to be a sensitive marker of intrapartum stressors. The lack of an arterial/venous difference facilitates cord blood collection, but frequent hemolysis is a problem when using the standard analysis method.

Haftungsausschluss: Dieser Abstract wurde mit Hilfe von Künstlicher Intelligenz übersetzt und wurde noch nicht überprüft oder verifiziert.