Einzelzellbiologie

Abstrakt

Interferon-related secretome plays a crucial role in PD-L1 expression in the tumor microenvironment following direct interaction between immune cells and tumor cells

Yuan-Qin Yang, Jonathan Howard DeLong and Kang-Jian Zhang

PD-L1, also known as CD274 or B7-H1, is an important immune checkpoint protein. Binding of PD-L1 to its receptor PD-1 induces an inhibitory signal that suppresses the immune response through various mechanisms, such as inhibiting the proliferation of CD8+ T effector cells. This research has led to the development of promising clinical drugs, including anti-PD-1 antibodies such as Keytruda (pembrolizumab, Merck) and Opdivo (nivolumab, BMS), as well as the anti-PD-L1 antibody Tecentriq (atezolizumab, Roche) and other peptides and small molecule inhibitors for cancer immunotherapy. However, the mechanism by which tumor cells expressing PD-L1 regulate the function of invading immune cells within the tumor microenvironment is not well understood.