Biologie und Medizin

Abstrakt

Infection and Incidence of Herpes Viruses in Neonates in Aktobe Region of Kazakhstan

Galina Dautovna Zhumagaliyeva and Marzya Abdramanovna Mamyrbayeva

The aim of the study was to investigate the incidence and morbidity of herpes viruses in neonates in Aktobe region of Kazakhstan. Were analyzed The aggregate data of neonatal mortality in the Republic of Kazakhstan for the period 2010-2014 were analyzed, a retrospective analysis of medical records of 1,544 patients was conducted, 938 sera of blood of unhealthy newborns were surveyed for markers of intrauterine infection. Aktobe is a region with average neonatal mortality rates (1.33‰) due to late mortality (0.59‰) despite the low rate of early neonatal mortality (0.74‰). The infant mortality rate from congenital anomalies among children under one year in Aktobe region and in Aktobe city decreased in 2011 compared to 2010 (9.9 and 9.5 per 10,000 of live births, respectively) and increased again in 2012 (by 1.1 and 4.5, respectively). The proportion of mortality from cytomegalovirus infection (CMVI) in the general mortality rate amounted in 2010 to 50%; in 2011, 60%; and in 2012, 66.7%. The frequency of neonatal jaundice among newborns in Aktobe amounted to 4.9-7.5%. Intrauterine infectious viral hepatitis among newborns occurs at a frequency of 1.15 and 2.2%. The incidence rate of hepatitis per 1,000 babies is not equal—13.5, 21.9, 11.5. A high prevalence of cytomeg- alovirus (CMV) antibodies (99.0%) and herpes simplex virus (HSV) (92.5%) was detected. Prevalent was the detection of IgG (91.7%) in patients with clinical manifestations of CMVI. According to the infectious morbidity, the frequency of incidence of CMVI is 4.61, and the frequency of “infection” is 52.5 in general in 57.2 per 1,000 children in the first year of life. Similarly, the frequency of incidence of herpes infection is 0.35, and the frequency of “infection” is 20.97 in general in 21.3 per 1,000 children in the first year of life. The so-called infected with CMV children—234 (51%)—and infected with HSV—63 (34%)—had the obvious clinical manifestations, so they should be attributed to the illness.