Indiziert in
- Öffnen Sie das J-Tor
- Genamics JournalSeek
- CiteFactor
- Kosmos IF
- Scimago
- Ulrichs Zeitschriftenverzeichnis
- Elektronische Zeitschriftenbibliothek
- RefSeek
- Hamdard-Universität
- EBSCO AZ
- Verzeichnis der Abstract-Indexierung für Zeitschriften
- OCLC – WorldCat
- Proquest-Vorladungen
- Gelehrtersteer
- STRASSE
- Virtuelle Bibliothek für Biologie (vifabio)
- Publons
- Genfer Stiftung für medizinische Ausbildung und Forschung
- Google Scholar
Nützliche Links
Teile diese Seite
Zeitschriftenflyer
Open-Access-Zeitschriften
- Allgemeine Wissenschaft
- Biochemie
- Bioinformatik und Systembiologie
- Chemie
- Genetik und Molekularbiologie
- Immunologie und Mikrobiologie
- Klinische Wissenschaften
- Krankenpflege und Gesundheitsfürsorge
- Landwirtschaft und Aquakultur
- Lebensmittel & Ernährung
- Maschinenbau
- Materialwissenschaften
- Medizinische Wissenschaften
- Neurowissenschaften und Psychologie
- Pharmazeutische Wissenschaften
- Umweltwissenschaften
- Veterinärwissenschaften
- Wirtschaft & Management
Abstrakt
Evaluation of Angiogenic Potential of 1-Monocaproin Using Chick Chorioallantoic Membrane Assay
Palaniappan Maheswari and Kasthuri Revathi
1-Monocaproin, a 1-monoacylglycerol, was synthesized with the reaction of glycidol by chromium-caproic fatty acid complexes and was found to be amphiphilic in nature. Synthesized 1-monocaproin was characterized by thin-layer chromatography, and the residual chromium was analyzed using inductively coupled plasma mass spectroscopy. Vascular endothelium growth factor (VEGF)-mediated angiogenesis pathways are being targeted for the development of novel drugs suitable for inhibition or stimulation of angiogenesis in various pathologies. In the chicken egg Chorioallantoic membrane (CAM) assay, 1-monocaproin exhibited VEGF-induced neovascularization in a dose-dependent manner. Synthesized 1-monocaproin was found to show the angiogenic effect at a dose concentration equivalent to VEGF at 1,000 ppm. The results thus suggest that 1-monocaproin should be considered as a useful drug candidature targeting angiogenesis in coronary artery disease, stroke, and postsurgical therapy.