Biologie und Medizin

Abstrakt

Epidemiological Assessment of Testosterone Levels in Women Population: A Factorial Analysis of Cell Proliferation

Victor Eshu Okpashi, Bonaventure Chukwunonso Obi, Innocent Okagu and Prince Odilichukwu Okoroafor

In women, testosterone is produced in the ovaries, adrenal glands, and fat cells. Women may produce much or little of testosterone. Excess Testosterones and deficiencies are among the common hormonal disorders in women. Testosterone in women plays a role in the hormonal cascade that kick-starts puberty and stimulates hair growth. In adult women, testosterone is necessary for estrogen synthesis and have played a key role in the prevention of bone loss, sexual desire, and satisfaction. Testosterone can affect the breast and it is well implicated in testosterone therapy for women. The need to bring about shreds of evidence linking specific human health effect due to testosterone imbalance in women for the assessment of reproduction insufficiency was the purpose of this investigation. Results from clinical observations and epidemiological studies implicate testosterone imbalance as a significant treatment of public health. A total of 186 women of Eket Community in Akwa Ibom State, Nigeria, were purposively and disproportionately selected, using simplified sample size formula. Blood serums were prepared using the blood obtained from donors. The in vitro assay of the testosterone and sex hormone binding globulin was achieved using enzyme-linked immunosorbent assay technique. The ratio of sex hormone binding globulin to testosterone was calculated and free testosterone was obtained. The in vitro hormonal quantification showed that 38 (20%) of women had testosterone level above the reference range - 4.42-32.02 ng/ml/mmol/L, while 148 (80%) had low testosterone level. This showed that a fraction of women in Eket community with high levels of a form of testosterone called "free" testosterone may have polycystic ovary syndrome (PCOS), characterized by irregular or absent of menstrual periods, infertility, blood sugar disorders (pre-diabetes and type 2 diabetes), and, in some cases, symptoms such as acne and excess hair growth may set in.