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Abstrakt
Effect of Guibourtia tessmannii extracts on blood lipids and oxidative stress markers in triton WR 1339 and high fat diet induced hyperlipidemic rats
CF Nyangono Beyegue, RM Chakokam Ngangoum, D Kuate, JL Ngondi, J Enyong Oben
The present study evaluated the effect of aqueous and hydroethanolic extracts of Guibourtia tessmannii on blood lipids and oxidative stress markers in both triton (WR-1339) and high fat diet induced hyperlipidemic rat models. Results revealed that treatment of tritonized hyperlipidemic rats with G.tessmannii extracts at dose of 200 mg/kg BW resulted in a significant reduction in total cholesterol (TC), triglyceride (TG) and lipid peroxide (MDA) levels (p<0.05). In high fat diet induced hyperlipidemic rats model, feeding with the atherogenic diet for 30 days significantly increased the plasma levels of TG, TC, LDL-C, LDL/HDL, TC/HDL ratios, as well as a significant elevation of lipid peroxide levels in both plasma and liver. Co-administration of the G.tessmannii extracts at dose of 200 mg/kg BW along with a high fat diet reversed these changes. These beneficial effects could be attributed to the antioxidant activities of bioactive ingredients in both extracts.