Pharmaceutica Analytica Acta

Abstrakt

Design and Development of Multi Particulate System for Targeted Drug Delivery Using Natural Polymer

Uzma Farooq, Rishabha Malviya and Pramod Kumar Sharma

Okra mucilage has been used to reduce the cholesterol level since microspheres has formulated by using okra mucilage to develop a synergistic effect. Biodegradable and biocompatible okra (Abelmoschus esculentus) mucilage was extracted for the development of controlled release multi-particulate drug delivery system. Surface morphological characteristics were studied using scanning electron microscopy. Concentrated solution containing different proportion of natural materials i.e. okra mucilage and sodium alginate were used to formulate the microspheres in the calcium chloride solution. Calcium chloride act as a cross linking agent, when react with sodium alginate form a calcium alginate, since developed a gel like microspheres. The formulated microspheres were thereafter loaded with losartan potassium. These formulations were evaluated by different parameters like percentage yield, particle size, particle shape, surface morphology and in vitro release properties etc. Approximately nine formulations were studied in which F6 formulation has shown a major differentiating factor as per study. High % yield in F7 formulation was found to be 99.01%. All the formulations showed good swelling characteristics in simulated intestinal fluid (pH 7.4). During study of drug release, the rate and extent of drug release decreased significantly with increase of concentration of polymer and calcium chloride, release data shows that F6 formulation has shown a major differentiating factor given the best result of drug release which was found to be 91.50% after 6 hr in simulated intestinal fluid (pH 7.4). The prepared microspheres show controlled release effect of losartan potassium. The study has revealed that natural materials can be used for formulation of controlled release microspheres and will provide more opportunities for further study.