Comparative Evaluation of In Vitro Thrombolytic Activity of Four Medicinal Plants

Naga Bharathi M, Devi Sirisha G, Manoj kumar M, Sai Kanaka durga L, Harshitha K, Satyasree D, Srinivas K

Thrombolytic drugs are mainly used for the treatment of myocardial infarction, which occurs due to thrombus formation and causes tissue necrosis. Currently plasminogen activator (t-PA), streptokinase, urokinase are used, but the major drawback was adverse effects like hemorrhage, allergic reactions and lack of specificity.The present study was aimed to investigate in vitro thrombolytic activity of methanolic and aquoes extract of Phyllanthus niruri, Nyctanthes arbor- tristis, Syzygium cumini and Clome gynandra, where streptokinase and water were used as positive and negative control. Among the medicinal plants Nyctanthes arbor- tristis(aqueous) extract exhibited highest thrombolytic activity by clot lysis of 14.2%, followed by Cleome gynandra(aqueous) extract with 7.7% of clot lysis and Phyllanthus niruri(methanol) extract with 6.7% clot lysis when compared with Standard streptokinase showed clot lysis of 22.3% while the negative control water 2.2% lysis of clot.From our findings it was observed that among all plants Nyctanthes arbor- tristis(aqueous) extract showed highest thrombolytic activity. Therefore, further studies required to isolate active component(s).