Nahed Fahmy Helal, Nashwa Mamdouh Samra, Eman Abdel Ghany Abdel Ghany and Ebtehal Adel Said
Objective: We investigated whether the Score for Neonatal Acute Physiology II (SNAP II) can predict mortality and/or organ dysfunction (OD) in neonatal sepsis. Methods: Eighty Egyptian newborns hospitalized for neonatal sepsis were studied in a multicenter, prospective, observational study to determine whether SNAP II administered in the first 12 hours after admission would predict mortality and/or OD. Results: The mean SNAP II score was significantly higher in babies who developed stars or OD than in those who survived and improved (P=0.003 and P=0.001, respectively). Individual parameters of SNAP II did not contribute equally to the risk of death, but lower mean arterial blood pressure and lower blood pH were significantly associated with OD and death (P=0.002). ROC curves for SNAP II score ≥ 40 show moderate predictive accuracy and sensitivity of 90.4% and 88.9% for OD and death, respectively. Conclusion: SNAP II score can predict mortality and hypersensitivity in neonatal sepsis.