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Abstrakt
ANTIBACTERIAL AND TOXICOLOGICAL EFFECTS OF THE AQUEOUS EXTRACT OF MANGIFERA INDICA STEM BARK ON ALBINO RATS
Chidozie VN, Adoga GI, Chukwu OC, Chukwu ID,Adekeye AM
Mangifera indica (MI) otherwise known as mango is popular for its sweet succulent fruits eaten as food. The leaves and the stem bark are used as herbal medicine. Many studies have been conducted on the phytochemical constituents and many work done to scientifically prove their efficacy as antibacterial and antifungal agents. However it appears that work on its effectiveness as an antityphoid agent and toxicity study of aqueous MI stem bark extract are still lacking. In this study investigation on the antibacterial activities was done on salmonella typhi and six other bacteria. Acute toxicity studies was also carried out using albino rats and fixed doses of the extract as follows; 10mg/kg, 100mg/kg, 1000mg/kg, 2900mg/kg and 5000mg/kg body weight of the animals. The extract was found to be active against all the test bacteria except streptococcus faecalis. There was no sign of toxicity and no death recorded even at 5000mg/kg. The single oral dose did not produce any statistical significant changes at p < 0.05 in haemtological parameters like the HB and HCT, the biochemical parameters like the AST and ALT when the control group was compared to the test group. The histological examination also compare well with the control.