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Abstrakt
Anti-Aβ antibodies in the fight against Alzheimer's disease
Mehmet Bostanciklioglu
Alzheimer's disease (AD) is the most common form of dementia. Due to increasing evidence, amyloid-β plaques have become the most important targets of therapy. Although hundreds of studies have been conducted in animals and humans, the success of this therapeutic approach is still disappointing. The present study investigates the mechanism of action of anti-Aβ antibodies, the type of antibodies and immunization, why treatment success is limited despite numerous studies and the huge budget allocated to AD research, and what are the latest developments in immunotherapy. The need for early treatment of AD is greater than ever. Therefore, new studies should be designed aimed at developing new conformation-specific antibodies and new techniques that facilitate the crossing of the blood-brain barrier (BBB) by these new conformation-specific antibodies to the central nervous system (CNS).