Indiziert in
- Öffnen Sie das J-Tor
- Genamics JournalSeek
- Forschungsbibel
- RefSeek
- Verzeichnis der Indexierung von Forschungszeitschriften (DRJI)
- Hamdard-Universität
- EBSCO AZ
- OCLC – WorldCat
- Gelehrtersteer
- Publons
- MIAR
- Euro-Pub
- Google Scholar
Nützliche Links
Teile diese Seite
Zeitschriftenflyer
Open-Access-Zeitschriften
- Allgemeine Wissenschaft
- Biochemie
- Bioinformatik und Systembiologie
- Chemie
- Genetik und Molekularbiologie
- Immunologie und Mikrobiologie
- Klinische Wissenschaften
- Krankenpflege und Gesundheitsfürsorge
- Landwirtschaft und Aquakultur
- Lebensmittel & Ernährung
- Maschinenbau
- Materialwissenschaften
- Medizinische Wissenschaften
- Neurowissenschaften und Psychologie
- Pharmazeutische Wissenschaften
- Umweltwissenschaften
- Veterinärwissenschaften
- Wirtschaft & Management
Abstrakt
ALK5, A Novel Binding Partner of Lumican in Corneal Wound Healing
Yujin Zhang and Chia-yang Liu
Recently, Yamanaka et al. published a paper in PLOSone, which revealed that recombinant mouse lumican (Lum) protein purified from E. coli was capable of interacting with transforming growth factor beta receptor 1 (TGFβR1, ALK5) and further demonstrated that the interaction between these two is critical for the wound healing activity of Lum in vitro and in vivo. This paper was important because it addressed a central issue about Lum; namely its cell surface receptor mediating the multiple biological functions as a matrikine in physiological and pathophysiological conditions. The results convincingly demonstrate that ALK5 is the Lum receptor, which has remained elusive for the past two decades since the suggestion of a putative Lum receptor by Funderburgh et al., in 1997.